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In this match-up, the 49ers are set to play against the Cowboys for the ninth time in the postseason.
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The 49ers have won 11 consecutive games and have outscored their opponents by considerable margins.
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San Francisco's ground attack is averaging 138.8 yards per game, good enough to rank eighth in the league.
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The 49ers have also forced 30 turnovers this season, which ranks second in the league.
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On the other hand, the Cowboys have been struggling with driving deep into late-stage Super Bowl competition since they last won in 1995.
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The Cowboys have also been on a fourth consecutive road trip, extending back to the conclusion of this campaign's regular season.
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The 49ers are expected to win this match-up with a score of 28-20.
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In the second match-up, the Bills are set to play against the Bengals.
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The Bengals have been struggling with multiple significant injuries to their offensive line, which has left the door open for the Bills to get another shot at the elusive brass ring.
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The Bills narrowly escaped a life-and-death struggle against the Dolphins last week.
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The Bengals are expected to lose this match-up with a score of 30-23.
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NFL Divisional Round Picks: Jaguars vs. Chiefs, Eagles vs. Giants